ChemInform Abstract: Highly Enantioselective Asymmetric Darzens Reactions with a Phase Transfer Catalyst.

Abstract

Catalyst. -The new PTC is used to catalyze an unprecedented highly enantioselective Darzens reaction of α-chloro ketones with aldehydes to give optically active epoxides. High yields and enantioselectivities are obtained for various aromatic as well as aliphatic aldehydes. The method is also applicable to cyclic ketones (VI) albeit, somewhat lower yield is observed for the methoxy substituted derivative (VId). -(LIU, Y.; PROVENCHER, B. A.; BARTELSON, K. J.; DENG*, L.; Chem. Sci. 2 (2011) 7, 1301-1304, http://dx.doi.org/10.1039/c1sc00137j ; Dep. Chem., Brandeis Univ., Waltham, MA 02454, USA; Eng.) -S. Adam 41-086