ChemInform Abstract: Highly Efficient Diastereoselective Reduction of α‐Fluoroimines.

Abstract

Highly Efficient Diastereoselective Reduction of α-Fluoroimines. -The new methodology for the reduction of α-fluoroimines is based on the ability of fluorine and nitrogen to activate organosilanes which results in enhanced reducing reactivity and high diastereoselectivity. The approach is applicable for industrial-scale synthesis because the reaction is sequential and eliminates the use of ethereal solvents that are generally used in transition metal based chelation control synthesis. -(MALAMAKAL, R. M.; HESS, W. R.; DAVIS*, T. A.; Org. Lett.