2001
DOI: 10.1002/chin.200113197
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ChemInform Abstract: Heterospirocyclic N‐(2H‐Azirin‐3‐yl)‐L‐prolinates: New Dipeptide Synthons.

Abstract: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

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Cited by 1 publication
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“…Like other α,α-disubstituted α-amino acids, the presence of 5 forces peptides to form β-turns [12] or helical conformations. In our studies towards the synthesis of such sterically congested oligopeptides with a helical conformation by using the 'azirine/oxazolone method' [25][26][27][28][29], we introduced N-(2,2-dimethyl-2H-azirin-3-yl)proline methyl ester as a dipeptide (Aib-Pro) synthon [30][31][32] as well as other dipeptide (Xaa-Pro) synthons, including those with Xaa being a heterocyclic α-amino acid [13,33,34]. The aim of the present study was the synthesis of (S)-N-(1-aza-6-thiaspiro[2.5]oct-1-en-2-yl)proline methyl ester (1c) and its use as a…”
mentioning
confidence: 99%
“…Like other α,α-disubstituted α-amino acids, the presence of 5 forces peptides to form β-turns [12] or helical conformations. In our studies towards the synthesis of such sterically congested oligopeptides with a helical conformation by using the 'azirine/oxazolone method' [25][26][27][28][29], we introduced N-(2,2-dimethyl-2H-azirin-3-yl)proline methyl ester as a dipeptide (Aib-Pro) synthon [30][31][32] as well as other dipeptide (Xaa-Pro) synthons, including those with Xaa being a heterocyclic α-amino acid [13,33,34]. The aim of the present study was the synthesis of (S)-N-(1-aza-6-thiaspiro[2.5]oct-1-en-2-yl)proline methyl ester (1c) and its use as a…”
mentioning
confidence: 99%