ChemInform Abstract: Heteroatom Analogues of Bemoradan: Chemistry and Cardiotonic Activity of 1,4‐Benzothiazinylpyridazinones.

Combs, Donald W.; Rampulla, M. S.; Demers, James P.; Falotico, Robert; Moore, J. B.

doi:10.1002/chin.199222218

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2015

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“…A further research in this field in search of safer and more potent compounds led to the discovery of milrinone and its analogs (Bekhit and Baraka, 2005;Abadi et al, 1999). To develop SAR in the series, several pyridazinone derivatives of amrinone were also synthesized (Combs et al, 1992;Bakewell et al, 1990;McCall et al, 1986;Pastelin et al, 1983). Their mechanism of action was established, and a five-point model and pharmacophore were identified (Leclerc et al, 1986;Erhardt et al, 1988;Bristol et al, 1984).…”

Section: Cardiotonicmentioning

confidence: 99%

Pyridazinone: an important element of pharmacophore possessing broad spectrum of activity

Dubey¹,

Bhosle

2015

Med Chem Res

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In the last few years, the pyridazine derivatives have been found to exhibit a wide range of pharmacological activities. A large number of research articles and patents described them, and several drugs based on its nucleus have come into light. Pyridazinone, a derivative of pyridazine, was initially exploited in search of cardiovascular drugs and for its use in agrochemicals, but later on this nucleus was found to be associated with plethora of activities. In this article, we have reviewed the influence of structural changes on the pharmacodynamic profile of the pyridazinone moiety.

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