ChemInform Abstract: H₂SO₄/Silicagel: Highly Efficient Catalyst for the Synthesis of α‐Aminonitriles Using Trimethylsilyl Cyanide.

Abstract

Nitriles Q 0520 H2SO4/Silicagel: Highly Efficient Catalyst for the Synthesis of α-Aminonitriles Using Trimethylsilyl Cyanide. -A simple, convenient, and practical method for the synthesis of title compounds (IV) (11 examples) is developed. It proceeds through one-pot three-component coupling of aldehydes, amines and Tms-CN using sulfuric acid adsorbed on silica gel as relatively green catalyst. -(OSKOOIE, H. A.; HERAVI*, M. M.; SADNIA, A.; JANNATI, F.; BEHBAHANI, F. K.; Monatsh.