ChemInform Abstract: Formation of Substituted Cyclobutanes in the Reaction of 2‐(2‐Methyl‐2‐ propenyl)‐3‐chloromethyloxirane with Aromatic Hydrocarbons.

Abstract

Formation of Substituted Cyclobutanes in the Reaction of 2-(2-Methyl-2-propenyl)-3-chloromethyloxirane with Aromatic Hydrocarbons.-The title reaction in the presence of AlCl3 gives substituted cyclobutanes (III) (5 examples) in good yields. Further cyclobutane derivatives (IV), (V) or (VII) are available by simple side chain modifications of (III). -(AKHMEDOV, M. A.; SARDAROV, I. K.; AKHMEDOV, I. M.; KOSTIKOV, R. R.; KISIN, A. V.; BABAEV, N. M.; Zh.

Quantum chemical calculations and interpretation of electronic transitions and spectroscopic characteristics belonging to 1-(3-Mesityl-3-methylcyclobutyl)-2-(naphthalene-1-yloxy)ethanone

“…Firstly, a mixture of 1-mesityl-1-methyl-3-(2-chloro-1-oxoethyl)cyclobutane is synthesized as reported previously [18]. Namely, (2.64 g, 10 mmol), 1-naphthol (1.44 g, 10 mmol) and K 2 CO 3 (1.51 g, 11 mmol) are refluxed for 8 h in 200 ml dry acetone.…”

Evaluation of Antifungal and Antiproliferative Effects of Two Different Organic Compounds with Cyclobutane Ring

“…The compound 3 was synthesized and characterized according to our previous papers [18,19]. Briefly, a mixture of 1-methyl -1-phenyl -3-(2-chloro-1-oxoethyl) cyclobutane (0.01 mol, 2.225 g), which was synthesized using the protocol defined by Akhmedov et al [20], triethylamine (0.01 mol, 1.0 g) and phthalimide (0.01 mol, 1.471 g) in acetonitrile was stirred for 4 hours. After purification the product obtained was crystallized from ethanol.…”

Investigation of the molecular structure of 4-(3-methyl-3-phenylcyclobutyl)-2-[2-(3-methylbenzylidene)hydrazinyl]thiazole in the gas and solid phases

“…The starting materials 3-methylbenzaldehyde and thiosemicarbazide were purchased from Merck and used as received. The -haloketone 3-(2-chloro-1-oxoethyl)-1-methyl-1-phenylcyclobutane was synthesized according to a literature procedure (Akhmedov et al, 1991). A mixture of 3-methylbenzaldehyde (1.2015 g, 10 mmol) and thiosemicarbazide (0.9114 g, 10 mmol) in ethanol (10 ml) was refluxed for 2 h. Subsequently, a solution of -haloketone (2.2271 g, 10 mmol) in ethanol (20 ml) was added dropwise at room temperature and the mixture was stirred for 3 h (thin-layer chromatography).…”