ChemInform Abstract: Formation and Reactivity of 5‐Aminopenta‐2,4‐dienals: Useful Intermediates for Nitrogen Heterocycles Synthesis

Abstract

Review: 102 refs.

Structural and Mechanistic Insights into the Pseudomonas fluorescens 2-Nitrobenzoate 2-Nitroreductase NbaA

“…3-HAA is also naturally produced via the degradation of L-tryptophan through the kynurenine pathway, with important neuropsychiatric implications (13). It is likely that bacterial 3-HAA synthesis, if safer and more efficient than chemical synthesis (14), will benefit the development of pharmaceutical agents active against the 3,4-dioxygenases associated with human and animal brain diseases (15,16). It has been shown that the nbaAB system, when expressed in Escherichia coli lacking the activity for degradation of 2-aminobenzoate and 3-HAA, is not as effective in reducing 2-NBA as expected based on in vitro enzyme assays (6).…”