“…Another way to a variety of 1,4-benzothiazin-1,1-dioxides is described [111]. Chlorosulfonation of 3,4-difluoroaniline gave 2-amino-4,5-difluorobenzenesulfonyl chloride which was converted into the corresponding sodium sulfinate 119, which reacts with different bromocontaining ketones to give fluorinated 1,4-benzothiazin-1,1-dioxides 120-122 (Scheme 46).…”