ChemInform Abstract: Flavones and Triterpenes from the Leaves of Vitex peduncularis.

Rudrapaul, Prasenjit; Грүнер, Маргит; Knoelker, H.‐J.; Dinda, Biswanath

doi:10.1002/chin.201545220

Cited by 5 publications

(4 citation statements)

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“…Our study was performed to ascertain the analgesic, antioxidant, cytotoxic, thrombolytic, and anti-inflammatory activities of MEMC using experimental (in vivo and in vitro assays) and computational (molecular docking and ADME/T analysis) approaches. The qualitative phytochemical screening revealed that MEMC contains several phytoconstituents, including alkaloids, carbohydrates, flavonoids, phenols, tannins, saponins, reducing sugars, glycosides, and terpenoids [18][19][20][21]. Our quantitative phytochemical assay illustrated that MEMC has a TPC of 148.67 mg GAE/g and a TFC of 24 mg QE/g.…”

Section: Discussionmentioning

confidence: 92%

Computational and Pharmacological Studies on the Antioxidant, Thrombolytic, Anti-Inflammatory, and Analgesic Activity of Molineria capitulata

Shovo

Tona

Mouah

et al. 2021

CIMB

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Molineria capitulata is an ornamental plant that has traditionally been used to treat several chronic diseases. The present study was designed to examine the antioxidant, cytotoxic, thrombolytic, anti-inflammatory, and analgesic activities of a methanolic extract of M. capitulata leaves (MEMC) using both experimental and computational models. Previously established protocols were used to perform qualitative and quantitative phytochemical screening in MEMC. A computational study, including molecular docking and ADME/T analyses, was performed. The quantitative phytochemical analysis revealed the total phenolic and flavonoid contents as 148.67 and 24 mg/g, respectively. Antioxidant activity was assessed by examining the reducing power of MEMC, resulting in absorbance of 1.87 at 400 µg/mL, demonstrating a strong reduction capacity. The extract exhibited significant protection against blood clotting and showed the highest protein denaturation inhibition at 500 µg/mL. In both the acetic acid-induced writhing and formalin-induced paw-licking models, MEMC resulted in significant potential pain inhibition in mice. In the computational analysis, 4-hydroxybenzaldehyde, orcinol glucoside, curcapital, crassifogenin C, and 2,6-dimethoxy-benzoic acid displayed a strong predictive binding affinity against the respective receptors. These findings indicated that M. capitulata possesses significant pharmacological activities to an extent supported by computational studies.

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Section: Discussionmentioning

confidence: 92%

Computational and Pharmacological Studies on the Antioxidant, Thrombolytic, Anti-Inflammatory, and Analgesic Activity of Molineria capitulata

Shovo

Tona

Mouah

et al. 2021

CIMB

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“…Kirtikar and Basu [59] reported that in Chota Nagpur regions, localities use its bark to address aches and pains. Many compounds such as peduncularaside, iridoidanguside, Vitexin, triterpenoids, and flavonoids [60,61,62,11,63,64,65] , pachypodol, ursolic acid, and 2-hydroxy-ursolic acid [66,41,67,68] , crisimartin, 3α-friedeliniol, genkwanin, and, 3βfriedeliniol [24] are present in the leaves. Researchers have already examined the various parts of V. peduncularis for exploring bioactive substances and evaluated their efficacy [69] .…”

Section: Conventional Applicationsmentioning

confidence: 99%

Importance of conserving Vitex peduncularis: A depleting forest resource with immense ethnopharmacological uses

Kumari.¹,

Sinha²,

Mishra³

2023

Pharma Innovation

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Vitex peduncularis, vernacularly known as 'Charaigorwa' is a large evergreen tree having numerous ethnopharmacological uses and belongs to the family Lamiaceae. The species is globally known for its usage to cure multifarious human health issues in traditional as well as contemporary medicines. The species exerts high bioactivity due to the presence of several secondary metabolites, including flavonoids, Vitexin, iridoid glycosides, pachypodol, ursolic acid, 2-hydroxy-ursolic acid terpenoids. Due to the high demands of V. peduncularis in pharmaceutical industries, the species is being exploited indiscriminately, pushing it towards the abyss of extinction. Immediate conservation measures are required to sustain the available natural population through multidisciplinary scientific interventions. This article cumulates the importance of the species directing towards its specialized pharmacological characteristics and its therapeutic uses. It also highlights the research gaps needed to be filled up for judicial use of the species conserving its depleting genetic resources.

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“…All flavonoids obtained from this species were tested for biological activities and exhibited moderate trypanocidal activity due to the increase in methylation of the hydroxyl group. Meanwhile, a flavonoid, which was isolated from the leaves of large evergreen tree V. penduncularis was 4′-acetoxy-5-hydroxy-6,7-dimethoxyflavone ( 126 ) [ 120 ].…”

Section: Secondary Metabolites Isolated From Vitex ...mentioning

confidence: 99%

Traditional Medicinal Uses, Phytochemistry, Biological Properties, and Health Applications of Vitex sp.

Kamal

Asni

Rozlan

et al. 2022

Plants

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The genus Vitex is also known as a chaste tree, in which it is a large shrub native to the tropical and subtropical regions of the world. A diverse range of species is distributed throughout Southern Europe, the Mediterranean, and Central Asia. The Vitex tree, including its leaves and fruits, has been used for herbal remedies in the form of pastes, decoctions, and dried fruits since ancient times. This article aimed to prepare a comprehensive review of traditional uses and secondary metabolites derived from Vitex sp., including the chemical compounds, biological activities, application of Vitex in human clinical trials, toxicology and safety, marketed products, and patents. The scientific findings were obtained using a number of search engines and databases, including Google Scholar, PMC, and ScienceDirect. Vitex species are well known in pharmacology to have medicinal values, such as anti-inflammatory, antibacterial, antifungal, antimicrobial, antioxidant, and anticancer properties. Previous studies reported that some species are proven to be effective in treating diseases, such as diabetes, and improving female health. A total of 161 compounds from different Vitex species are reported, covering the literature from 1982 to 2022. A chemical analysis report of various studies identified that Vitex exhibited a wide range of phytoconstituents, such as iridoid, diterpenoid, ecdysteroid, and flavonoid and phenolic compounds. Apart from that, the review will also discuss the application of Vitex in human clinical trials, toxicology and safety, marketed products, and patents of the genus. While the extracts of the genus have been made into many commercial products, including supplements and essential oils, most of them are made to be used by women to improve menstrual conditions and relieve premenstrual syndrome. Among the species, Vitex agnus-castus L. is the only one that has been reported to undergo clinical trials, mainly related to the use of the genus for the treatment of mastalgia, menstrual bleeding problems, amenorrhea, menorrhagia, luteal insufficiency, and premenstrual syndrome. Overall, the review addresses recent therapeutic breakthroughs and identifies research gaps that should be explored for prospective research work.

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ChemInform Abstract: Flavones and Triterpenes from the Leaves of Vitex peduncularis.

Cited by 5 publications

References 0 publications

Computational and Pharmacological Studies on the Antioxidant, Thrombolytic, Anti-Inflammatory, and Analgesic Activity of Molineria capitulata

Computational and Pharmacological Studies on the Antioxidant, Thrombolytic, Anti-Inflammatory, and Analgesic Activity of Molineria capitulata

Importance of conserving Vitex peduncularis: A depleting forest resource with immense ethnopharmacological uses

Traditional Medicinal Uses, Phytochemistry, Biological Properties, and Health Applications of Vitex sp.

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