ChemInform Abstract: Facile Synthesis of α‐Methylidene‐γ‐butyrolactones: Intramolecular Rauhut—Currier Reaction Promoted by Chiral Acid—Base Organocatalysts.

Abstract

Facile Synthesis of α-Methylidene-γ-butyrolactones: Intramolecular Rauhut--Currier Reaction Promoted by Chiral Acid-Base Organocatalysts. -Highly functionalized α-methylidene-γ-butyrolactones are formed enantioselectively from prochiral dienone enolates in the presence of chiral organocatalysts (CHOC). The reaction fails if either the dienone α-positions or the side chain terminal olefin are substituted. -(TAKIZAWA, S.; NGUYEN, T. M.-N.; GROSSMANN, A.; SUZUKI, M.; ENDERS, D.; SASAI*, H.; Tetrahedron 69 (2013) 3, 1202-1209, http://dx.