ChemInform Abstract: Facile One‐Pot Synthesis of Tetrahydroisoquinolines from Amino Acids via Hypochlorite‐Mediated Decarboxylation and Pictet—Spengler Condensation.

Abstract

Facile One-Pot Synthesis of Tetrahydroisoquinolines from Amino Acids via Hypochlorite-Mediated Decarboxylation and Pictet-Spengler Condensation. -Oxidative decarboxylation of -amino acids provides the corresponding aldehydes which are converted into tetrahydroquinolines by addition of dopamine via Pictet--Spengler reaction. The two-step sequence is performed in a one-pot manner. -(MARESH*, J. J.; CROWE, S. O.; RALKO, A. A.; APARECE, M. D.; MURPHY, C. M.; KRZESZOWIEC, M.; MULLOWNEY, M. W.; Tetrahedron Lett. 55 (2014) 36, 5047-5051, http://dx.