ChemInform Abstract: Facile Method for 1,3‐Dipolar Cycloaddition Reaction of Azomethine Ylides: Highly Stereoselective Synthesis of Substituted Pyrrolidine Derivatives.

Abstract

Facile Method for 1,3-Dipolar Cycloaddition Reaction of Azomethine Ylides: Highly Stereoselective Synthesis of Substituted Pyrrolidine Derivatives. -Et2Zn-catalyzed, solvent-free 1,3-dipolar cycloaddition of azomethine ylides, derived from aldehydes (I) and glycine ester (II), with N-methylmaleimides gives pyrrolopyrrolidine derivatives (IV) with high endo-selectivity. -(YAVUZ, S.; OEZKAN, H.; TOK, G.; DISLI*, A.; J.