ChemInform Abstract: Exploration of Amino Alcohol Derivatives as Novel, Potent, and Highly Selective Sphingosine‐1‐phosphate Receptor Subtype‐1 Agonists.

Abstract

Exploration of Amino Alcohol Derivatives as Novel, Potent, and Highly Selective Sphingosine-1-phosphate Receptor Subtype-1 Agonists. -PPI-4955 ((R)-I) is found to be a potent and selective preclinical candidate with an excellent in vivo potency and dose responsiveness and markedly improved overall in vivo pharmacodynamic properties upon oral administration. -(EVINDAR*, G.; et al.; Bioorg. Med. Chem. Lett