ChemInform Abstract: Evaluation of 5‐cis‐Substituted Prolinamines as Ligands in Enantioselective, Copper‐Catalyzed Henry Reactions.

Abstract

DedicatedtoProf. Dr.D r. h.c. mult. Gerhard Bringmann on the occasion of his 65th birthday.Scheme1.The enantioselective, copper-catalyzed Henry reaction and aselection of diamine(4-7) [5a,j,p, 8a] and proline-derived (7,8) [5j,m] ligandst hat give 99 % ee with at least one aldehyde substrate.Scheme2.The proline-derived diamines 9 and 10,their metal complexes [M·9/10], and enantioselective, copper-catalyzed Henry reactions in the presence of the chiral diamine 9a. [9] [a]