ChemInform Abstract: Euphosalicin, a New Diterpene Polyester with Multidrug Resistance Reversing Activity from Euphorbia salicifolia

Abstract

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Synthesis of the C6–C14 Fragment of Euphosalicin

“…4 In 2001, the highly oxygenated diterpene euphosalicin (1) was isolated from Euphorbia salicifolia by Hohmann and co-workers. 5 Although it has a unique [11.3.0] bicyclic structure, it is closely related to the jatrophanes: formal incorporation of the jatrophane C18 methyl group into the macrocycle gives the euphosalicin skeleton as shown in Figure 1.…”