ChemInform Abstract: Enantioselective Synthesis of a 3,5,5‐Trialkylated Tetronic Acid Derivative.

Abstract

Furan derivatives R 0060Enantioselective Synthesis of a 3,5,5-Trialkylated Tetronic Acid Derivative. -A multi-step enantioselective procedureallows the synthesis of the tetronic acid derivative (XV) via Dieckmann condensation of ester (XI) as a key step. This approach realizes access to the tetronic acid moiety of the acylphloroglucinol-type natural product perforatumone. -(TAKAO*, K.-I.; KOJIMA, Y.; MIYASHITA, T.; YASHIRO, K.; YAMADA, T.; TADANO, K.-I.; Heterocycles 77 (2009) 1, 167-172; Dep. Appl.