ChemInform Abstract: Enantioselective Copper‐Catalyzed Quinoline Alkynylation.

Abstract

The catalytic system of CuBr and the newly developed chiral StackPhos ligand is successfully applied for the three‐component reaction of quinolines with terminal alkynes and ethyl chloroformate leading to dihydroquinolines such as (IV) and (VII), which are readily converted into natural compounds (‐)‐angustureine (Va), (+)‐galipinine, and (+)‐cuspareine (VIII).