Abstract:Enantioselective Allylation of Aldehydes Catalyzed by Diastereoisomeric Bis(tetrahydroisoquinoline) N,N'-Dioxides. -Asymmetric allylation of aromatic (I) and α,β-unsaturated aldehydes (IV) with allyltrichlorosilane (II) proceeds smoothly in THF in the presence of (Sax)-bis(tetrahydroisoquinoline N-oxide) to give the products (III) and (V) in good yields and moderate to high enantioselectivity. Interestingly, the corresponding (R ax )-ligand does not catalyze this reaction in THF but needs MeCN or CH2Cl2 as sol… Show more
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