ChemInform Abstract: Electroreductive Defluorination of Trifluoromethyl Ketones and Trifluoroacetic Acid Derivatives.

Abstract

Electroreductive Defluorination of Trifluoromethyl Ketones and Trifluoroacetic Acid Derivatives. -Silyl ethers (III) and (VII), silyl (O,O-, O,S-, and O,N-) acetals, e.g. (V), and silylacetates like (X) are prepared by the title reaction from the corresponding trifluoromethyl precursors employing a carbon rod as anode, a lead plate as cathode, and Bu 4 NBr as supporting electrolyte. The alkylation of silylacetate (X) with electrophiles promoted by Bu 4 NF or KF/CuI provides α-alkylated-α,α-difluoroacetates in good yields.