ChemInform Abstract: EINIGE ANOMALE RK. DES CYCLOPENTYLMAGNESIUMCHLORIDS

Bobysheva, Z. I.; Volkova, V. A.; Ioffe, D. V.; Кузнецов, С. Г.; Stepanova, A. A.

doi:10.1002/chin.197304163

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Theoretical Potential and Actual Impurities In Cpma1

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2012

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“…The cyclopentylether 38 is reported once as the product of an “anomalous reaction of cyclopentylmagnesium chloride”, the attack of the Grignard reagent at the carbonyl-oxygen . Although benzoic acid 39 might be derived from phenylglyoxylic acid 36 by decarbonylation, this reaction is reported to occur only under oxidative and photolytic conditions .…”

Section: Theoretical Potential and Actual Impurities In Cpmamentioning

confidence: 99%

Carry Over of Impurities: A Detailed Exemplification for Glycopyrrolate (NVA237)

Allmendinger

Bixel

Clarke

et al. 2012

Org. Process Res. Dev.

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The original synthesis of glycopyrrolate (NVA237) was revised and shortened into an essentially one-pot process. Without isolating the intermediates, their purification became obsolete, thereby increasing the possibility of the carry over of impurities. For that reason, the actual, potential, and theoretical impurities of the starting materials cyclopentyl mandelic acid and 1-methyl-pyrrolidin-3-ol as well as byproducts which may occur during the synthesis were thoroughly investigated; furthermore, their transformation to possible impurities in the drug substance along the new synthetic route was performed to exclude them as actual impurities in the drug substance with certainty. The question is raised how detailed such investigationwhich are fairly manageable for a simple product like glycopyrrolateneed to be.

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Section: Theoretical Potential and Actual Impurities In Cpmamentioning

confidence: 99%