ChemInform Abstract: Efficient Synthesis of Aminopyridine Derivatives by Copper Catalyzed Amination Reactions.

Elmkaddem, Mohammed Kamal; Fischmeister, Cédric; Thomas, Christophe M.; Renaud, Jean‐Paul

doi:10.1002/chin.201024134

ChemInform

2010

DOI: 10.1002/chin.201024134

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ChemInform Abstract: Efficient Synthesis of Aminopyridine Derivatives by Copper Catalyzed Amination Reactions.

Mohammed Kamal Elmkaddem¹,

Cédric Fischmeister²,

Christophe M. Thomas³

et al.

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“…Note that 2-aminopyridines are either commercially available or readily synthesized via well-established transformation. 23 In addition, the structural diversity can be simultaneously achieved, for example, by switching the C3 symmetrical ( 3) isocyanide monomer to that with C2 symmetry (4) (Figure 1b). Owing to these synthetic advantages, a series of pyrimidazole-based COFs have been facilely constructed with diversified functionalities (Scheme 2).…”

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Pyrimidazole-Based Covalent Organic Frameworks: Integrating Functionality and Ultrastability via Isocyanide Chemistry

et al. 2020

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Development of new chemistry to simultaneously meet the demands for topology, connectivity, and functionality is highly desired in the research area of covalent organic frameworks (COFs). We explore herein the isocyanide chemistry so as to establish a facile paradigm to integrate functionality and ultrastability in COFs. Using the representative Groebke–Blackburn–Bienaymé (GBB) reaction based on isocyanide chemistry, we are able to construct a series of pyrimidazole-based COFs in one step from isocyanide, aminopyridine, and aldehyde monomers. Diversified functionalities have been bottom-up integrated by the simple replacement of readily available 2-aminopyridine monomers. Meanwhile, the ubiquitous formation of fused imidazole rings within the frameworks has guaranteed their ultrastability. In view of the rich synthetic possibilities provided by isocyanide chemistry, we expect that this contribution opens up a new avenue toward the divergent construction of robust COFs for practical applications.

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Pyrimidazole-Based Covalent Organic Frameworks: Integrating Functionality and Ultrastability via Isocyanide Chemistry

et al. 2020

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ChemInform Abstract: Efficient Synthesis of Aminopyridine Derivatives by Copper Catalyzed Amination Reactions.

Cited by 1 publication

References 1 publication

Pyrimidazole-Based Covalent Organic Frameworks: Integrating Functionality and Ultrastability via Isocyanide Chemistry

Pyrimidazole-Based Covalent Organic Frameworks: Integrating Functionality and Ultrastability via Isocyanide Chemistry

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