ChemInform Abstract: Efficient Procedure for the Preparation of Oligomer‐Free N^α‐Fmoc Amino Acids.

Abstract

Amino acids U 0400Efficient Procedure for the Preparation of Oligomer-Free N α -Fmoc Amino Acids.-A two-step procedure is employed to obtain peptide-free N-Fmoc amino acids. First, stable dicyclohexylammonium salts are prepared followed by the properly coupling with the protecting reagent. Attempts to reduce the two-step procedure to a one-pot process without isolation of the salt fail. The role of the intermediate salt in preventing unwanted oligomeric by-products is discussed. -(NOWSHUDDIN, S.; RAO, M. N. A.; REDDY*, A. R.; Synth. Commun. 39 (2009) 11, 2022-2031; Dep. Chem., Coll. Sci., Osmania Univ., Hyderabad 500 007, India; Eng.) -H. Haber 43-195