ChemInform Abstract: Efficient One‐Pot Synthesis of Propargylamines from Mannich Bases Through a Retro‐Mannich‐Type Fragmentation.

Abstract

Efficient One-Pot Synthesis of Propargylamines from Mannich Bases Through a Retro-Mannich-Type Fragmentation. -A novel method for the synthesis of propargylamines is developed by Cu-catalyzed coupling of Tbp-type Mannich bases with terminal alkynes and NCS (or NBS) as the oxidant. The reaction is unsuccessful in the presence of aromatic secondary amines [cf.(Ib)] and with an aliphatic alkyne [cf. (XI)]. -(ZHU, Y.; ZHAO, H.; WEI*, Y.; Synthesis 45 (2013) 7, 952-958, http://dx.