ChemInform Abstract: Efficient and Convenient Method for Synthesis of Benzofuran‐3‐acetic Acids and Naphthafuran‐Acetic Acids.

Basanagouda, Mahantesha; Narayanachar, Narayanachar; Majati, Iranna B.; Mulimani, Shiddappa S.; Sunnal, Satish B.; Nadiger, Rohit V.; Ghanti, Ashok S.; Gudageri, Siddeshwar F.; Naik, Ravi; Nayak, Akshata

doi:10.1002/chin.201605121

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2019

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“…This compound has been previously reported. 36 Benzo [b]thiophen-3-ylacetic Acid 15b. Yield: 54% (78 mg, 0.41 mmol).…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

Pd(OH)₂/C, a Practical and Efficient Catalyst for the Carboxylation of Benzylic Bromides with Carbon Monoxide

Wakuluk-Machado

Dewez

Baguia

et al. 2019

Org. Process Res. Dev.

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A simple, efficient, cheap, and broadly applicable system for the carboxylation of benzylic bromides with carbon monoxide and water is reported. Upon simple reaction with only 2.5 wt % of Pearlman's catalyst and 10 mol % of tetrabutylammonium bromide in tetrahydrofuran at 110°C for 4 h, a range of benzylic bromides can be smoothly converted to the corresponding arylacetic acids in good to excellent yields after simple extraction and acid−base wash. The reaction was found to be broadly applicable, scalable, and could be successfully extended to the use of ex situ-generated carbon monoxide and applied to the synthesis of the nonsteroidal anti-inflammatory drug diclofenac.

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“…This compound has been previously reported. 36 Benzo [b]thiophen-3-ylacetic Acid 15b. Yield: 54% (78 mg, 0.41 mmol).…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

Pd(OH)₂/C, a Practical and Efficient Catalyst for the Carboxylation of Benzylic Bromides with Carbon Monoxide

Wakuluk-Machado

Dewez

Baguia

et al. 2019

Org. Process Res. Dev.

View full text Add to dashboard Cite

show abstract

ChemInform Abstract: Efficient and Convenient Method for Synthesis of Benzofuran‐3‐acetic Acids and Naphthafuran‐Acetic Acids.

Cited by 1 publication

References 1 publication

Pd(OH)₂/C, a Practical and Efficient Catalyst for the Carboxylation of Benzylic Bromides with Carbon Monoxide

Pd(OH)₂/C, a Practical and Efficient Catalyst for the Carboxylation of Benzylic Bromides with Carbon Monoxide

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ChemInform Abstract: Efficient and Convenient Method for Synthesis of Benzofuran‐3‐acetic Acids and Naphthafuran‐Acetic Acids.

Cited by 1 publication

References 1 publication

Pd(OH)2/C, a Practical and Efficient Catalyst for the Carboxylation of Benzylic Bromides with Carbon Monoxide

Pd(OH)2/C, a Practical and Efficient Catalyst for the Carboxylation of Benzylic Bromides with Carbon Monoxide

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Pd(OH)₂/C, a Practical and Efficient Catalyst for the Carboxylation of Benzylic Bromides with Carbon Monoxide

Pd(OH)₂/C, a Practical and Efficient Catalyst for the Carboxylation of Benzylic Bromides with Carbon Monoxide