ChemInform Abstract: Designed Molecules That Fold to Mimic Protein Secondary Structures

Stigers, Kimberly D.; Soth, Michael; Nowick, James S.

doi:10.1002/chin.200022266

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2019

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“…Branched peptides, also known as peptide oligodendrimers, have recently attracted increased research interest because of their biological functions in protein-protein interaction [1][2][3][4], vaccine design [5,6], receptor-binding investigation [7], etc. In previous studies, the branched cyclic peptide exhibited improved half-life and enhanced selectivity of therapeutic peptide drugs [8,9].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Branched Peptides via a Side-Chain Benzyl Ester

Liu

Tian

et al. 2019

Methods in Molecular Biology

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Branched peptide as an attractive mimic of natural peptide is widely used in structural design of functional or therapeutic peptides, to improve their biological activity, stability, and pharmacokinetic properties. In this protocol, we employ a function group of side-chain benzyl ester as the precursor of hydrazide, which could be conveniently used to assemble a branch peptide by native chemical ligation or direct amidation. This method is convergent and efficient, and facilitates the synthesis and application of branched peptides.

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