ChemInform Abstract: Design, Microwave‐Assisted Synthesis and in silico Docking Studies of New 4H‐Pyrimido[2,1‐b]benzothiazole‐2‐arylamino‐3‐cyano‐4‐ones (III) as Possible Adenosine A_2B Receptor Antagonists.

Abstract

Design, Microwave-Assisted Synthesis and in silico Docking Studies of New 4H-Pyrimido[2,1-b]benzothiazole-2-arylamino-3-cyano-4-ones (III) as PossibleAdenosine A2B Receptor Antagonists. -(BALAKUMAR, C.; KISHORE, D. P.; RAO, K. V.; NARAYANA, B. L.; RAJWINDER, K.; RAJKUMAR, V.; RAO*, A. R.; Indian J.

7‐Amino‐2‐aryl/hetero‐aryl‐5‐oxo‐5,8‐dihydro[1,2,4]triazolo[1,5‐a]pyridine‐6‐carbonitriles: Synthesis and adenosine receptor binding studies

“…Thus, it was our thought of interest to further investigate any changes in affinity and selectivity towards ARs for a novel series of triazolopyridine derivatives ( 4a–4t ) with 7‐amino (NH 2 ) and 6‐carbonitrile (CN) group, while varying the substitution pattern at the 2‐position of the scaffold with various aryl/hetero‐aryl moieties (Figure ). In continuation of our interest in the search of novel ligands for adenosine receptors (Balakumar et al., ; Chandrasekaran et al., ; Deb et al., ; Kaur et al., ; Kishore, Balakumar, Rao, Roy, & Roy, ; Prasad et al., ; Sirisha et al., ; Veeraswamy et al., ) and in the light of the above‐mentioned literature reports, some novel 5‐oxo[1,2,4]triazolo[1,5‐ a ]pyridine‐6‐carbonitrile derivatives ( 4a–4t ) have been synthesized as potential selective ligands for hA 1 AR.…”

Green Synthesis, Experimental and Theoretical Studies to Discover Novel Binders of Exosomal Tetraspanin CD81 Protein

“… 20 , 21 Similarly, thiazole orange ( Figure 1 ) and a few benzothiazole derivatives have been reported for their applications in organic and medicinal chemistry. 22 …”

“…Earlier, we have reported novel quinoline bearing dihydropyridines for their inhibition against the lung cancer cell lines and obtained potential inhibition profiles . Compounds SYBR Green I and SYBR Safe (Figure ) are mainly used as dyes for the quantification of double-stranded DNA (quantitative PCR) and to visualize DNA (gel electrophoresis). , Similarly, thiazole orange (Figure ) and a few benzothiazole derivatives have been reported for their applications in organic and medicinal chemistry …”