ChemInform Abstract: Design and Synthesis of Tricyclic Derivatives as High Density Lipoprotein Cholesterol Enhancers.

Abstract

Design and Synthesis of Tricyclic Derivatives as High Density Lipoprotein Cholesterol Enhancers. -The synthesis and evaluation of imidazoisoquinolones [cf. (Va), (Vb)], related pyrimidoisoquinolones [cf. (VII)], and imidazonaphthyridines [cf. (Vc)] as high density lipoprotein cholesterol enhancing compounds is described. The synthetic route involves a novel and widely applicable one-step preparation of 3-carboxamidophthalides (III) from 2-acylbenzoic acids (I). -(ELOKDAH, HASSAN; CHAI, SIE-YEARL; HO,

Fe3O4@SiO2/collagen: An efficient magnetic nanocatalyst for the synthesis of benzimidazole and benzothiazole derivatives

“…Benzimidazole derivatives exhibit significant activity against several viruses such as HIV [3,8], influenza and human cytomegalovirus (HCMV) [8]; they also act as topoisomerase inhibitors [3], selective neuropeptide YY1 receptor antagonists [11], angiotensin II inhibitors [13], and smooth muscle cell proliferation inhibitors [14] and have much more importance in organic synthesis.…”

BF3·Et2O promoted selective synthesis of benzimidazoles

“…Benzimidazoles are also known for their anti-inflammatory [2], antibiotic [3], antihelmintic [4], anticancer [5] and antiviral activities [6]. In recent years benzimidazoles have been reported to act as topoisomerase I inhibitors [7], selective neuropeptide "Y Y 1" receptor antagonists [8], angiotensin II (A II) inhibitors [9], potential antitumor agents [10], smooth muscle cell proliferation inhibitors [11], and in diverse areas of chemistry [12].…”

One-Pot, Green Approach Synthesis of 2-Aryl Substituted Benzimidazole Derivatives Catalyzed by Water Extract of Papaya Bark Ash

“…It is well documented that benzimidazole and its derivatives extensively possesing wide range of spectrum of biological activities [8]. These compounds showed selective non-peptide LH-RH antagonist [9], lymphocyte specific kinase inhibitor [10], N-methyl-D-asparatate kinase inhibitor [11], N-methyl-D-aspartate antagonist [12], 5-lipoxygenase inhibitor [13], neuropeptide N-S5B polymerase inhibitor, neuropeptide YY1 receptor antagonist [14], thrombin inhibitors [15] and poly (ADP-ribose) polymerase inhibitors [16], DNA-miner groovebinding agents possess antitumour activity [17], topoisomerase inhibitors, angiotensin II inhibitors and proloferartion inhibitors [18]. In addition, various promising therapeutic applications of benzimidazole of derivatives found in antimicrobial [19], anticancer [20], antiulcer, antifungal [21], antihypertensive [22], herbicides [23], antihistamine activity [24] and other veterinary applications [25].…”