ChemInform Abstract: Design and Synthesis of Novel Cytotoxic Agents Based on Combined Framework of Quinoline and Nimesulide.

The title compound,12-dicarboximide was synthesized in high yield by reaction of N-(4-amino-2-phenoxyphenyl)methanesulfonamide and 9,10-dihydroanthracene-9,10-endo-α,β-succinic anhydride in glacial acetic acid. The structure of the compound was fully characterized by IR, 1 H and 13 C NMR, mass spectral analysis and elemental analysis. Keywords: sulfonamide; cyclic imide; nimesulideCyclic imides A (Scheme 1) represent an important class of bioactive molecules that shows a wide range of pharmacological activities such as androgen receptor antagonistic, anti-inflammatory, anxiolytic, antiviral, antibacterial, antitumor, antispasmodic, antinociceptive and antineoplastic properties [1][2][3][4][5][6][7][8][9][10][11][12][13].On the other hand N-(4-nitro-2-phenoxy phenyl)methane sulfonamide or nimesulide (B, Scheme 1), a preferential cyclooxygenase-2 (COX-2) inhibitor is one of the well known non-steroidal antiinflammatory drugs (NSAIDs) that has been utilized to treat pain and other inflammatory diseases. Because of their common anti-inflammatory properties and our interest in nimesulide (N-(4-nitro-2-phenoxy phenyl)methane sulfonamide) derivatives [14][15][16][17][18] as potential anti-inflammatory agents we decided to prepare compound C having structural features of both A and B (Scheme 1). OPEN ACCESS

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N-(4-Methylsulfonamido-3-phenoxyphenyl)-9,10-dihydro-9,10-ethanoanthracene-11,12-dicarboximide

Kavitha¹,

Prakash

Mukkanti

et al. 2011

Molbank

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ChemInform Abstract: Design and Synthesis of Novel Cytotoxic Agents Based on Combined Framework of Quinoline and Nimesulide.

Abstract: Among a variety of nimesulide‐derived Morita—Baylis—Hillman adducts (III), derivative (IIIc) shows the highest in vitro activity against human prostate cancer cell lines.

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N-(4-Methylsulfonamido-3-phenoxyphenyl)-9,10-dihydro-9,10-ethanoanthracene-11,12-dicarboximide

N-(4-Methylsulfonamido-3-phenoxyphenyl)-9,10-dihydro-9,10-ethanoanthracene-11,12-dicarboximide

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