ChemInform Abstract: DERIVATIVES OF ARENESULFONIC ACIDS. IX. SYNTHESIS OF 4‐SULFAMIDO‐5‐(P‐ALKOXYBENZYL)PYRIMIDINES

Abstract

Das 5‐(p‐Alkoxybenzyl)‐4,6‐dichlorpyrimidin (I) wird mit dem doppelten Überschuß des Natriumsalzes von der Sulfamide (II) in Acetamid bei 100°C umgesetzt.

Synthesis and hypoglycemic activity of benzenesulfonylurea and toluenesulfonamidopyrimidine derivatives

“…Reaction of 4-propoxy-3-carbmethoxybenzylchloride [12] with malonic ester produced the substituted malonic ester, cyclization of which with guanidium hydrochloride into 2-aminopyrimidine III was carried out in the presence of sodium methoxide [13]. 2-Sulfonamidopyrimidine II was prepared by reacting 2-aminopyrimidine III and p-toluenesulfonylchloride in anhydrous pyridine.…”