ChemInform Abstract: Current Trends in the Development of Nitric Oxide Donors

Hou, Yongchun; Jañczuk, Adam; Wang, P. G.

doi:10.1002/chin.199940254

Cited by 74 publications

(97 citation statements)

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“…NO, is an important cellular signaling molecule, involved in many physiological and pathological processes (Hou et al, 1999). It is reported that nitric oxide is involved in the acute renal failure since free radical nature of nitric oxide might contribute to tubular damage (Christo et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Effects of Lycopene Alone or Combined with Melatonin on Methotrexate-Induced Nephrotoxicity in Rats

Oğuz

Koçarslan²,

Tabur³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Methotrexate (Mtx), used for its anticancer and immunsuppresive properties, is known to be a nephrotoxic agent. We aimed to investigate the effects of lycopene (Lyc) alone or combined with melatonin (Mel) on Mtxinduced nephrotoxicity since both of these agents have antioxidant and anti-inflammatory effects. Nephrotoxicity was induced by intraperitoneal administration of methotrexate at a dose of 20 mg/kg. Treatment both with Lyc alone and Lyc combined with Mel provided significant reduction in tumor necrosis factor-alpha, interleukin 1-beta and ceruloplasmin levels in Mtx administered rats. Hovewer, Lyc combined with Mel provided a significant reduction also in NO levels. Hstopathological examination showed that there was an obvious improvement in the degenerative changes compared to Mtx administrated group with the Lyc combined Mel group giving best protection. In conclusion Lyc alone and combined with Mel provided significant improvement against renal damage caused by Mtx, preseumably via antioxidant and anti-inflammatory activities.

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Section: Discussionmentioning

confidence: 99%

Effects of Lycopene Alone or Combined with Melatonin on Methotrexate-Induced Nephrotoxicity in Rats

Oğuz

Koçarslan²,

Tabur³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…NO is an important messenger in many physiological functions, including immune regulation, vasodilation, cell survival and death, synaptic transmission, and plasticity [59] .…”

Section: Nitri C Oxide Synthase and Epilepsymentioning

confidence: 99%

Dysfunction of hippocampal interneurons in epilepsy

Liu

et al. 2014

Neurosci. Bull.

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Gamma-amino-butyric acid (GABA)-containing interneurons are crucial to both development and function of the brain. Down-regulation of GABAergic inhibition may result in the generation of epileptiform activity. Loss, axonal sprouting, and dysfunction of interneurons are regarded as mechanisms involved in epileptogenesis. Recent evidence suggests that network connectivity and the properties of interneurons are responsible for excitatory-inhibitory neuronal circuits. The balance between excitation and inhibition in CA1 neuronal circuitry is considerably altered during epileptic changes. This review discusses interneuron diversity, the causes of interneuron dysfunction in epilepsy, and the possibility of using GABAergic neuronal progenitors for the treatment of epilepsy.

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“…Nitric oxide is a gas under standard conditions, is one of several oxides of nitrogen, and is classified as a free radical. In mammals it is a potent vasodilator with short half-life, and an important cell signaling molecule that is involved in many physiological and pathological processes (Hou, 1999). It has been reported that localized NO synthesis in reproductive tissue plays an important role in regulating certain reproductive functions such as endometrial, cervical and myometrial activity (Telfer, 1995), embryo implantation (Battaglia, 2003) as well as embryo development (Chwalisz, 1999).…”

Section: Introductionmentioning

confidence: 99%

The Progesterone Receptor – To Be or Not to Be: The Anti-Inflammatory Effects of Progesterone in RAW 264.7 Cells

George¹

2017

stem

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It has been widely established that, in addition to its role in reproduction, progesterone (P4) also has potent anti-inflammatory effects. While the precise mechanisms have never been clearly elucidated in RAW 246.7 cells, it seems logical to assume that this response is -at least in part -a consequence of activation of and signaling through the progesterone receptor (P4-R). However, it has recently been shown that in a rat model, this anti-inflammatory effect is -in fact -independent of the progesterone receptor. In this project, the aim was to characterize this response by assaying nitric oxide production from lipopolysaccharide-challenged RAW 264.7 cells and ascertain the involvement of the P4-R. To determine the contribution of the receptor, RAW cells were incubated in the presence and absence of RU-486 -a potent P4-R antagonist. Our results indicate that the anti-inflammatory response of progesterone was in fact through the activation of the P4-R as cells incubated in RU-486 show an approximate 60% reversal of the inhibitory effect of P4 as compared to cells incubated in the absence of the antagonist. However, because we did not observe a complete reversal, suggests that perhaps other receptors come into play which will be addressed in future studies. Creative Commons LicenseThis work is licensed under a Creative Commons Attribution 4.0 License.This article is available in Proceedings of the Interdisciplinary STEM Teaching and Learning Conference:https://digitalcommons.georgiasouthern.edu/stem_proceedings/vol1/iss1/8 The Progesterone Receptor -To Be or Not to Be: The Anti-inflammatory Effects of Progesterone in RAW 264.7 CellsChristopher I Brandon Jr., Georgia Gwinnett College Bagie M. George, Georgia Gwinnett College Abstract: It has been widely established that, in addition to its role in reproduction, progesterone (P4) also has potent anti-inflammatory effects. While the precise mechanisms have never been clearly elucidated in RAW 246.7 cells, it seems logical to assume that this response is -at least in part -a consequence of activation of and signaling through the progesterone receptor (P4-R). However, it has recently been shown that in a rat model, this anti-inflammatory effect is -in fact -independent of the progesterone receptor. In this project, the aim was to characterize this response by assaying nitric oxide production from lipopolysaccharide-challenged RAW 264.7 cells and ascertain the involvement of the P4-R. To determine the contribution of the receptor, RAW cells were incubated in the presence and absence of RU-486 -a potent P4-R antagonist.Our results indicate that the anti-inflammatory response of progesterone was in fact through the activation of the P4-R as cells incubated in RU-486 show an approximate 60% reversal of the inhibitory effect of P4 as compared to cells incubated in the absence of the antagonist. However, because we did not observe a complete reversal, suggests that perhaps other receptors come into play which will be addressed in future studies.

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ChemInform Abstract: Current Trends in the Development of Nitric Oxide Donors

Cited by 74 publications

References 1 publication

Effects of Lycopene Alone or Combined with Melatonin on Methotrexate-Induced Nephrotoxicity in Rats

Effects of Lycopene Alone or Combined with Melatonin on Methotrexate-Induced Nephrotoxicity in Rats

Dysfunction of hippocampal interneurons in epilepsy

The Progesterone Receptor – To Be or Not to Be: The Anti-Inflammatory Effects of Progesterone in RAW 264.7 Cells

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