ChemInform Abstract: Corollosporine, a New Phthalide Derivative from the Marine Fungus Corollospora maritima Werderm. 1069.

Liberra, K.; Jansen, Robert W.; Lindequist, Ulrike

doi:10.1002/chin.199847275

Cited by 13 publications

(14 citation statements)

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“…In addition, transcripts corresponding to the polyketide metabolism such as phenolic phthiocerol and phthiocerol biosynthesis were expressed preferentially in freshwater ( File S3 ). Phtalide derivatives are important compounds resulting from the polyketide metabolism and have been previously described for C. maritima ( Liberra et al 1998 ). Hence, production of phtalides may be favored when salinity decreases in the environment of the fungus.…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, it is useful for measuring changes and evaluating the ecological disturbance on coastal sandy beaches due to its moderate sensitivity to pollution. It has also been recognized to produce a new phthalide exhibiting antibacterial activity against Staphylococcus aureus and other microorganisms, and it represents a hydrocarbonoclastic species able to use n-hexadecane, n-tetradecane, L-hexadecene, and pristane as sole carbon sources for growth ( Kohlmeyer and Kohlmeyer 1979 ; Kirk et al 1991 ; Liberra et al 1998 ; González and Hanlin 2010 ).…”

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confidence: 99%

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Comparative Transcriptome Analysis of the Cosmopolitan Marine Fungus Corollospora maritima Under Two Physiological Conditions

Vélez

Alejandri-Ramírez

González

et al. 2015

G3 Genes|Genomes|Genetics

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Marine sandy beaches represent dynamic environments often subject to harsh conditions and climate fluctuations, where natural and anthropogenic inputs of freshwater from fluvial and pluvial sources alter salinity, which has been recognized as a key variable affecting the distribution of aquatic organisms and influencing critical physiological processes. The marine arenicolous fungus Corollospora maritima is a worldwide-distributed saprobe that has been reported to present tolerance to freshwater. Here, we present a transcriptome analysis that will provide the first insight of the genomic content for this fungus and a gene expression comparison between two different salinity conditions. We also identified genes that are candidates for being differentially expressed in response to environmental variations on salinity during the fungal growth. The de novo reconstruction of C. maritima transcriptome Illumina sequencing provided a total of 14,530 transcripts (16 megabases). The comparison between the two growth conditions rendered 103 genes specifically overexpressed in seawater, and 132 genes specifically up-regulated under freshwater. Using fungal isolates collected from different beaches, the specific environmental regulation of particular transcript differential expression was confirmed by RT-qPCR. To our knowledge, this is the first analysis that explores the marine fungus C. maritima molecular responses to overcome freshwater stress, and these data could shed light to understand the fungal adaptation and plasticity mechanisms to the marine habitat.

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Comparative Transcriptome Analysis of the Cosmopolitan Marine Fungus Corollospora maritima Under Two Physiological Conditions

Vélez

Alejandri-Ramírez

González

et al. 2015

G3 Genes|Genomes|Genetics

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“…have previously been studied for secondary metabolite production. An isolate of C. maritima was obtained from driftwood, and culture extracts yielded the new phthalide metabolite, corollosporine ( 51 ), which demonstrated antibacterial activity against Staphylococcus aureus, Bacillus subtilis , and Escherichia coli (Liberra et al 1998 ). The second species studied was C. pulchella , also isolated from driftwood.…”

Section: New Metabolites Described From Marine Fungi ( Sensmentioning

confidence: 99%

An assessment of natural product discovery from marine (sensu strictu) and marine-derived fungi

et al. 2014

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The natural products community has been investigating secondary metabolites from marine fungi for several decades, but when one attempts to search for validated reports of new natural products from marine fungi, one encounters a literature saturated with reports from ‘marine-derived’ fungi. Of the 1000+ metabolites that have been characterized to date, only approximately 80 of these have been isolated from species from exclusively marine lineages. These metabolites are summarized here along with the lifestyle and habitats of their producing organisms. Furthermore, we address some of the reasons for the apparent disconnect between the stated objectives of discovering new chemistry from marine organisms and the apparent neglect of the truly exceptional obligate marine fungi. We also offer suggestions on how to reinvigorate enthusiasm for marine natural products discovery from fungi from exclusive marine lineages and highlight the need for critically assessing the role of apparently terrestrial fungi in the marine environment.

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“…Another example of polyketide-derived NP from marine fungi is corollosporine 20 (Figure 2). Corollosporine 20 is an antibacterial phthalide derivative produced by the fungus Corollospora maritima which was isolated from driftwood found near the island of Heligoland, Germany [41].…”

Section: Fungal Polyketidesmentioning

confidence: 99%

Selected Fungal Natural Products with Antimicrobial Properties

Jakubczyk

Dussart

2020

Molecules

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Fungal natural products and their effects have been known to humankind for hundreds of years. For example, toxic ergot alkaloids produced by filamentous fungi growing on rye poisoned thousands of people and livestock throughout the Middle Ages. However, their later medicinal applications, followed by the discovery of the first class of antibiotics, penicillins and other drugs of fungal origin, such as peptidic natural products, terpenoids or polyketides, have altered the historically negative reputation of fungal “toxins”. The development of new antimicrobial drugs is currently a major global challenge, mainly due to antimicrobial resistance phenomena. Therefore, the structures, biosynthesis and antimicrobial activity of selected fungal natural products are described here.

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ChemInform Abstract: Corollosporine, a New Phthalide Derivative from the Marine Fungus Corollospora maritima Werderm. 1069.

Cited by 13 publications

References 0 publications

Comparative Transcriptome Analysis of the Cosmopolitan Marine Fungus Corollospora maritima Under Two Physiological Conditions

Comparative Transcriptome Analysis of the Cosmopolitan Marine Fungus Corollospora maritima Under Two Physiological Conditions

An assessment of natural product discovery from marine (sensu strictu) and marine-derived fungi

Selected Fungal Natural Products with Antimicrobial Properties

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