ChemInform Abstract: Copper Triflate: An Efficient Catalyst for Direct Conversion of Secondary Alcohols into Azides.

Khedar, Poonam; Pericherla, Kasiviswanadharaju; Kumar, Anil

doi:10.1002/chin.201432079

Cited by 1 publication

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“…Density Functional Theory (DFT) computational studies agree with the initial oxidation of AgF to an Ag(II)-species by K 2 S 2 O 8 to give an alkyl radical that reacts with PhSO 2 N 3 to provide the intermediate I-9, which finally evolves to the final product. A direct azidation using Cu(OTf) 2 as the catalyst and TMS-N 3 as the azide source was reported by Kumar and co-workers as a mild route to convert benzylic alcohols into the corresponding azides (Scheme 10) [59]. Copper catalysis was largely employed for azidation of C(sp 2 ) atoms.…”

Section: Azidation Of Substrates Bearing a Leaving Groupmentioning

confidence: 99%

Transition Metal Catalyzed Azidation Reactions

et al. 2020

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A wide range of methodologies for the preparation of organic azides has been reported in the literature for many decades, due to their interest as building blocks for different transformations and their applications in biology as well as in materials science. More recently, with the spread of the use of transition metal-catalyzed reactions, new perspectives have also materialized in azidation processes, especially concerning the azidation of C–H bonds and direct difunctionalization of multiple carbon-carbon bonds. In this review, special emphasis will be placed on reactions involving substrates bearing a leaving group, hydroazidation reactions and azidation reactions that proceed with the formation of more than one bond. Further reactions for the preparation of allyl and vinyl azides as well as for azidations involving the opening of a ring complete the classification of the material.

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Section: Azidation Of Substrates Bearing a Leaving Groupmentioning

confidence: 99%