ChemInform Abstract: Copper‐Catalyzed Diboration of Ketones: Facile Synthesis of Tertiary α‐Hydroxyboronate Esters.

Abstract

Copper-Catalyzed Diboration of Ketones: Facile Synthesis of Tertiary α-Hydroxyboronate Esters. -The in-situ generation of the (ICy)CuOtBu catalyst from (ICy)CuCl and NaOtBu provides convenient reaction conditions to achieve the high catalyst efficiency. Diboration of a variety of functionalized ketones proceeds with moderate to high yields. The products are converted to the corresponding α-hydroxyboronate esters upon purification on silica gel. The reactions with (VII) and (IX) proceed with complete or high diastereoselectivities, respectively. -(MCINTOSH, M. L.; MOORE, C. M.; CLARK*, T.