ChemInform Abstract: Copper‐Catalyzed Cross‐Dehydrogenative Coupling of N‐Arylacrylamides with Chloroform Using tert‐Butyl Peroxybenzoate as Oxidant for the Synthesis of Trichloromethylated 2‐Oxindoles.

Abstract

Synthesis of Trichloromethylated 2-Oxindoles. -A Cu-catalyzed cross dehydrogenative coupling of N-arylacrylamides with chloroform is achieved using tert-butyl peroxybenzoate as oxidant, and trichloromethylated oxindoles are obtained in excellent yield and regioselectivity. This reaction is assumed to proceed by cascade addition of CCl 3 radicals and aryl cyclization. -(CHAN, C.-W.; LEE, P.-Y.; YU*, W.-Y.; Tetrahedron Lett. 56 (2015) 20, 2559-2563, http://dx.