ChemInform Abstract: Convenient Preparation of Primary Amides via Activation of Carboxylic Acids with Ethyl Chloroformate and Triethylamine under Mild Conditions.

Abstract

The amidation of N-protected -amino acids proceeds without racemization. -(NOGUCHI, T.; SEKINE, M.; YOKOO, Y.; JUNG, S.; IMAI*, N.; Chem. Lett. 42 (2013) 6, 580-582, http://dx.

In Silico Profiling of Histone Deacetylase 8 Inhibitory Activity: A Computational Analysis of Novel Dipeptide-Based Compounds Cross-Linked with Hydroxamic Acid

“…The structure of the proposed compounds 2A-D The design of the proposed compounds 2A-D New compounds containing Indole (as a cap) cross-linked with a hydroxamic acid group (as a ZBG zinc binging group) through amino acid linkers, and a scheme was proposed to synthesize the designed compounds 2A-D, Scheme 1, which was constructed by using ChemOffice software (ChemDraw Professional -19.1.0.8). Basically, it includes the reaction of Boc-ltryptophan carboxylic acid with the primary amine group of the other amino acid to form an amide bond as a dipeptide, which reacts with the primary amino group of different linkers to form an amide linkage, Bocdipeptide compounds [24]. Then, Bocdipeptide compounds will react with hydroxylamine hydrochloride, leading to the formation of the Boc final proposed compounds, 1A-D [24,25], and the deprotection of these compounds to give the deprotected final compounds, 2A-D [26,27].…”

“…Basically, it includes the reaction of Boc-ltryptophan carboxylic acid with the primary amine group of the other amino acid to form an amide bond as a dipeptide, which reacts with the primary amino group of different linkers to form an amide linkage, Bocdipeptide compounds [24]. Then, Bocdipeptide compounds will react with hydroxylamine hydrochloride, leading to the formation of the Boc final proposed compounds, 1A-D [24,25], and the deprotection of these compounds to give the deprotected final compounds, 2A-D [26,27].…”