ChemInform Abstract: Control of Six Contiguous Stereocenters in an Asymmetric Organocatalytic One‐Pot Michael/Michael/Aldol Addition Sequence.

Abstract

One-Pot Michael/Michael/Aldol Addition Sequence. -The reaction of β-ketoesters, aromatic nitroalkenes and aromatic α,β-unsaturated aldehydes provides highly substituted cyclohexanes with 6 contiguous stereocenters including a quaternary one. High diastereo-and enantioselectivity is observed. -(ENDERS*, D.; URBANIETZ, G.; CASSENS-SASSE, E.; KEESS, S.; RAABE, G.; Adv. Synth. Catal. 354 (2012) 8, 1481-1488, http://dx.doi.org/10.1002/adsc.201200120 ; Inst. Org. Chem., RWTH Aachen, D-52074 Aachen, Germany; Eng.) -Y. Steudel 40-058