ChemInform Abstract: Construction of 3‐Amino‐2‐oxindoles by Direct Amination of Aniline or α‐Amino‐Acid Derivatives to 3‐Bromooxindoles.

Abstract

Construction of 3-Amino-2-oxindoles by Direct Amination of Aniline or-Amino-Acid Derivatives to 3-Bromooxindoles. -The Ni-catalyzed asymmetric amination of 3-bromooxindoles with anilines is developed. In the presence of a bisoxazolidine catalyst moderate ee's are obtained. Moreover, the uncatalyzed reaction with amino acid esters gives low diastereoselectivities. -(ZHAO, M.; LI, N.-K.; ZHANG, Y.