Abstract:Conjugate Addition Reactions of Metalated Alkyl Pyridines. A Direct Route to 6-Substituted Pyridones.-The reaction of metalated alkyl pyridines with α,β-unsaturated ketones yields 1,2-and/or 1,4-addition products. Deprotection of (VII) using fresh prepared Raney-Ni results in formation of the pyridone (IX), a type of compound required as structural subunit in many biologically active compounds. -(KRAUS, G. A.; VINES, D. R.; MALPERT, J. H.; Tetrahedron 51 (1995) 5, 1337-1344; Dep. Chem., Iowa State Univ., Ames,… Show more
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