ChemInform Abstract: Competitive Reactions in the Synthesis of Nitrendipine.

Abstract

Reaction of the methyl benzylideneacetoacetate (Ia) with the ethyl acetoacetate (II) gives nitrendipine (IIIc) as the main product, together with the symmetrical esters (IIIa) and (IIIb).

Efficient One-Pot Synthesis of 1,4-Dihydropyridino[3,2-c]coumarins

“…香豆素衍生物是一类广泛存在于自然界中的重要 的杂环化合物, 具有明显的抗凝结、抗癌症及抗 HIV 等 生物活性 [4] . 其中吡啶并香豆素类化合物由于具有抑制 单胺氧化酶 [5] 、抗肿瘤 [6] 、止痛 [7] 、抗菌 [8] [9] (结构式 A), 二 氢喹啉并[3,2-c]香豆素 [10] (结构式 B), 具有抗肿瘤活性 的四氢喹啉并[3,2-c]香豆素 [11] (结构式 C)等, 成为香豆 素类化合物研究领域中的一个热点. 最近, 我们以稠杂环化合物为研究对象, 先后合成 了具有潜在生物活性的含吡啶 [12] 、吡喃 [13] 、呋喃 [14] 、香 豆素 [15] [17] 受到关注, 但在碘作用下的该类反应报道不 多 [18] .…”

Quinolin-6-Amines: Synthesis and Biological Evaluation

“…Due to its sweet odor, it was frequently used in perfumes since 1882. Coumarin and its derivatives extensively used as building block in heterocyclic synthetic chemistry for their versatile biological activities including antibacterial [2][3][4][5] antifungal [6][7][8][9][10], herbicidal [11], antitumor [12][13], anti-HIV [14], anticoagulant [15], anticonvulsant [16][17], anti-inflammatory [18][19], antimalarial [20] activities. In addition, these compounds are used as additives in food and cosmetics [21], dyes for tuning lasers [22][23][24][25].…”

Octahedral Co(II) and Ni(II) complexes of Schiff bases, semicarbazone and thiosemicarbazone, synthesis, biological, spectral, and thermal studies

“…Others display antitubercular activity [8] or show insecticidal properties [9]. These compounds have important pharmaceutical value because of their anticoagulant and antitumor activities [10][11][12][13].…”