ChemInform Abstract: Chingazumianine, a Novel Dichlorinated Alkaloid from Corydalis koidzumiana.

Abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Antiviral chlorinated daphnane diterpenoid orthoesters from the bark and wood of Trigonostemon cherrieri

“…The dichlorovinyl moiety observed in compounds 1-6 and 10 is particularly rare in natural products and, to the best of our knowledge, this is the second time that this functionality has been encountered in higher plants (Chan et al, 2000). The biosynthetic origin of these chlorine atoms is not elucidated yet but we hypothesized the implication of a non-heme iron, O 2 , a-ketoglutarate-dependent halogenase (Allard et al, 2012).…”

“…Indeed, if organohalogens are commonly encountered in marine organisms, they are rarely isolated from higher plants. Furthermore, the dichlorovinyl moiety is particularly scarce in higher plants since it has only been found in the structure of chingazumianine, a probable artifactual alkaloid isolated from the species Corydalis koidzumiana (Chan et al, 2000). The possible implication of a specific type of enzyme (non-heme iron, O 2 , a-ketoglutarate-dependent halogenase) in the halogenation process of these natural products has been discussed in our previous publication (Allard et al, 2012).…”