ChemInform Abstract: CHARACTERIZATION OF SURFACTANT VESICLES AS MEMBRANE MIMETIC AGENTS. 2. TEMPERATURE‐DEPENDENT CHANGES OF THE TURBIDITY, VISCOSITY, FLUORESCENCE POLARIZATION OF 2‐METHYLANTHRACENE, AND POSITRON ANNIHILATION IN SONICATED DIOCTADECYLDIMETHYLAMMONIUM CHLORIDE

Kawasaki, Koji; Romero, Alejandro; Djermouni, Belkacem; Ache, Hans J.; Fendler, János H.

doi:10.1002/chin.197944073

Cited by 2 publications

(2 citation statements)

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“…The phase transition between gel and liquid crystal is the origin of many biomembrane functions [17]. In the case of the synthetic bilayer, the presence of the phase transition has been inferred or proved for several dialkylammonium salts by a variety of physical techniques such as differential scanning calometry of the hydrated salt [13], NMR line broadening [4, 181, fluorescence depolarization [ 18, 191, turbidity [IS], and positron annihilation [19]. The kinetic study on the catalysis by dialkylammonium membranes also indicated anomalous temperature dependence which was ascribable to the phase transition [20, 21, 221.…”

Section: Introductionmentioning

confidence: 99%

Phase Transition of the Bilayer Membrane of Synthetic Dialkyl Amphiphiles as Studied by Differential Scanning Calorimetry

Okahata

Ando

Kunitake

1981

Ber Bunsenges Phys Chem

118

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Biophysikalische Chemie / Elektronenmikroskopie / Fliissige Kristalle / Membranen / Phasenum wandlungenThe phase transition behavior of dilute aqueous solutions of the bilayer membrane of dialkyl (CIz to CIS in most cases) amphiphiles was investigated by differential scanning calorimetry (DSC). The extent of the sample dispersion affected the DSC behavior for dialkyl amphiphiles with ammonium, phosphate and sulfonate head groups. The well-sonicated aqueous sample of the ammonium amphiphiles showed broader transition peaks at lower temperatures than the corresponding frozen sample did. The discrepancy became less pronounced when the interacting group was introduced at or near the head group. The dual DSC behavior was not observed for amphiphiles with nonionic (polyoxyethylene) and zwitterionic (phosphocholine) head groups. The phase transition temperature (0-80°C) was enhanced progressively with increasing alkyl chain lengths (C,z to CIS), but the transition enthalpy (2 -12 kcal/mol) did not obey simple relations.were shown to form bilayer membranes in these and other laboratories [3-111. We can now conclude that the bilayer formation is not a specific property of biolipids but a physicochemical property common to many of the dialkyl amphiphiles. These synthetic bilayer membranes, especially dialkylammonium membranes, has been examined concerning their structures, physicochemical properties, and physical and chemical functions [ 121.

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Section: Introductionmentioning

confidence: 99%

Phase Transition of the Bilayer Membrane of Synthetic Dialkyl Amphiphiles as Studied by Differential Scanning Calorimetry

Okahata

Ando

Kunitake

1981

Ber Bunsenges Phys Chem

118

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“…During the last 30 years positron annihilation spectroscopy has been applied to several different materials that resemble biological membrane. More over, several studies on artificial membranes are performed that reveal similar phase behavior as in biological membranes [31]. For a reason unknown to the author, the research on biological membranes stopped in mid 80's and further development on positron studies or theory on biological membranes has not occurred until know.…”

Section: -Experimental Techniques For Biophysical Researchmentioning

confidence: 99%

Probing The Microstructure Of Biomaterials With Positrons

Sane¹,

Tuomisto²,

Vattulainen³

et al. 2009

Biophysical Journal

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Voids in biological membranes are vital to the diffusion characteristics of the membranes and as such information gained from e.g. void sizes elucidates the understanding of the functionality of the membrane. In this thesis the focus is on lipid bilayers, a type of membrane that exists in almost all organisms as a diffusion barrier surrounding the cells. The lipid bilayer consists of hydrophilic and hydrophobic parts that can form the bilayer structure in aqueous solution and the structural properties of the inner core of the bilayer (aka. hydrocarbon tail area) have a strong effect on the diffusion of particles through the bilayer. One of the key elements in the bilayer structure is the distribution and size of the free volume pockets, voids. The size of the voids depend both on the lipid type, but as well as the structural parameters of the bilayer, so called phase behaviour of the bilayer structure. Positron annihilation lifetime spectroscopy is a widely used tool to characterize atomic-scale structural properties of both solid state and soft matter and as such the correlation with positron (or to be specific positronium, the bound state of positron and electron) lifetime and the size of voids in e.g. polymers has been observed. In this thesis positron annihilation lifetime spectroscopy has been applied to probe the voids in lipid bilayers in several manners: Firstly as a proof-of-concept-type of experiment reveals the feasibility of positron annihilation lifetime spectroscopy as a tool to detect subtle differences in the void sizes depending on the lipid concentration in aqueous solution, secondly it is found possible to characterize the phase transition temperature by observing the change of void sizes below and above the phase transition temperature. In addition, the effect of dopants, namely cholesterol, on the bilayer structure is studied as a function of cholesterol concentration. The feasibility of positron annihilation lifetime spectroscopy to study intact tissues in-situ is also presented in a study where the temperature-induced structural transition of mammalian lens is observed and traced down to the lipids the lens strongly consists of.

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ChemInform Abstract: CHARACTERIZATION OF SURFACTANT VESICLES AS MEMBRANE MIMETIC AGENTS. 2. TEMPERATURE‐DEPENDENT CHANGES OF THE TURBIDITY, VISCOSITY, FLUORESCENCE POLARIZATION OF 2‐METHYLANTHRACENE, AND POSITRON ANNIHILATION IN SONICATED DIOCTADECYLDIMETHYLAMMONIUM CHLORIDE

Cited by 2 publications

References 1 publication

Phase Transition of the Bilayer Membrane of Synthetic Dialkyl Amphiphiles as Studied by Differential Scanning Calorimetry

Phase Transition of the Bilayer Membrane of Synthetic Dialkyl Amphiphiles as Studied by Differential Scanning Calorimetry

Probing The Microstructure Of Biomaterials With Positrons

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