ChemInform Abstract: Characterization of Eight New Secondary Metabolites from the Mutant Strain G‐444 of Tubercularia sp. TF5.

Abstract

TF5. -Eight new metabolites, including new sesquiterpenoids (I), a new backbone sesquiterpene rearranged from guaiane, two disecoguaianes (II), two new dihydroisocoumarins (IV), and one new tetralone (III) are isolated together with ten known compounds. None of the new compounds shows antimicrobial activities. -(LU, C.-H.; LIU, S.-S.; WANG, J.-Y.; WANG, M.-Z.; SHEN*, Y.-M.; Helv. Chim. Acta 97 (2014) 3, 334-344, http://dx.

A New Pair of Pentaketide Diastereoisomers from Aspergillus melleus YIM PHI001

“…Reduction of the aldehyde in A-3 into the primary alcohol give A-4, and formation of 1, 2 by nucleophilic attack of the primary alcohol on either site of the carbons in one of the two epoxide groups and hydration in the rest epoxide group, and the similar biosynthetic conversion was also reported in aspilactonol B, C [5]. Other known compounds were isolated and determined as chrysogeside D (3) [7], aspinonene (4) [6], aspinotriols A (5) and B (6) [6], 22E,24R-ergosta-7,22-diene-3,5,6-triol (7) [8], mellein (8) [9], 4-hydroxymellein ( 9) [10].…”

A remote C–C bond cleavage–enabled skeletal reorganization: Access to medium-/large-sized cyclic alkenes

“…1C , left). This strategy has also provided a general and operationally simple approach for the synthesis of skeletally and functionally diverse fluoroalkylated medium-/large-sized cyclic alkenes or bridged ring systems, which constitute the core structures of many biologically active natural products, such as siamol ( 1 ), spartidienedione ( 2 ), tuberculariol D ( 4 ), longpene B ( 5 ), etc. ( Figs.…”

A Novel Steroid Derivative and a New Steroidal Saponin from Endophytic Fungus Xylaria sp

“…Moreover, in consideration of the 13 C and 1 H NMR data (Table 1), it was reasonable to consider that there should be four rings in the compound. The 16 known compounds were identified as 16--D-mannopyranosyloxyisopimar-7-en-19-oic acid (3) [4], 4,7-dihydroxy-13tetradeca-2,5,8-trienolide (4) [5,6], mutolide (5) [7], cerebroside C (6) [8], 1,8-dihydroxynaphthol 1-O-α-D-glucopyranoside ( 7) [9], cytochalasin C (8) [10], cytochalasin Q ( 9) [10], zygosporin G ( 10) [11], 4β-hydroxyxylaranol B (11) [12], xylaranol B (12) [13], 24Rergosta-7, 22-diene-3, 5, 6-triol ( 13) [14], halorosellinic acid ( 14) [15], 17-dehydroxyhalorosellinic acid ( 15) [16], 5-carboxymellein ( 16) [17], 2'-deoxyadenosine ( 17) [18], uracil ( 18) [19], respectively, by comparing their spectroscopic data with those reported.…”