ChemInform Abstract: Catalytic Asymmetric Allylation of 3,4‐Dihydroisoquinolines and Its Application to the Synthesis of Isoquinoline Alkaloids.

Abstract

Catalytic Asymmetric Allylation of 3,4-Dihydroisoquinolines and Its Application to the Synthesis of Isoquinoline Alkaloids. -An improved method allows formation of the 1-allylated tetrahydroisoquinolines (S)-and (R)-(III) with good enantioselectivity. These products can smoothly be converted into homolaudanosine (IV), crispine A (V), and the precursor (VI) of schulzeine A. -(MIYAZAKI, M.; ANDO, N.; SUGAI, K.; SEITO, Y.; FUKUOKA, H.; KANEMITSU, T.; NAGATA, K.; ODANAKA, Y.; NAKAMURA, K. T.; ITOH*, T.; J. Org. Chem. 76 (2011) 2, 534-542, http://dx.