ChemInform Abstract: Catalytic Antioxidant Activity of Diaryl Tellurides in a Two‐Phase Lipid Peroxidation Model.

Abstract

Catalytic Antioxidant Activity of Diaryl Tellurides in a Two-Phase Lipid Peroxidation Model.-The capacity of diaryl tellurides (12 examples), such as (I), (II), ( III), (IV), and (V), and of the oxide (VI), diaryl sulfides, ebselen, probucol, BHT, trolox and vitamin E to inhibit the azo-initiated peroxidation of linoleic acid in a two phase system of H2O and Ph-Cl containing N-acetylcysteine as thiol-type reducing agent in the aqueous phase are investigated. In catalytic amounts (40 µM), phenolic and nonphenolic diaryl tellurides inhibit efficiently peroxidation in the Ph-Cl layer until the thiol in the aqueous phase is completely oxidized to the corresponding disulfide. Trolox and vitamin E are efficient as antioxidants only on a stoichiometric basis. BHT, probucol, and ebselen exhibit poor antioxidant capacity, while some phenolic diaryl sulfides are moderately efficient inhibitors. -(VESSMAN, K.; EKSTROEM, M.; BERGLUND, M.; ANDERSSON, C.-M.; ENGMAN, L.; J.