ChemInform Abstract: Cardiotonic Agents. 1‐Methyl‐7‐(4‐pyridyl)‐5,6,7,8‐tetrahydro‐3(2H)‐isoquinolinones and Related Compounds. Synthesis and Activity.

Abstract

4‐Substituted cyclohexanone derivatives such as (IV), prepared from the acetal (I) as outlined in the reaction scheme, are acylated, yielding the 2‐acetylcyclohexanones (VI).

Efficient route to 2H-1,3-oxazines through ring expansion of isoxazoles by rhodium carbenoids

“…The synthesis of fused isoxazole 8 was achieved using a relatively straightforward approach starting from β-diketone 9, which in turn was readily prepared by literature procedures 8,9 from the commercially available mono-protected 1,4-cyclohexadione (Scheme 3). If the isoxazole forming reaction was allowed to run to completion, the resulting regioisomeric mixture of isoxazoles proved inseparable by chromatography at all subsequent steps.…”

Reactions of 1-Amino-5-Morpholino-6,7,8,9-Tetrahydrothieno[2,3-c] Isoquinoline- 2-Carbonitrile

“…Many of them exhibit important biological activities, for example, antiinflammatory, anti-microbial, anti-leukaemic, and anti-tumour properties, 2,3 anti-HIV, and other biological activities. [4][5][6][7][8] Tetrahydroisoquinolines have cardiovascular 9 activities and are useful in the treatment of Parkinson's disease. 10 Tetrahydropyrimidothienoisoquinolines are useful compounds as antianaphylactics, anti-inflammatories, and bacteriophage inhibitors.…”