ChemInform Abstract: Carbohydrate‐Containing Natural Products in Medicinal Chemistry

Abstract

Review: 88 refs.

Stereocontrolled 1,2-cis glycosylation as the driving force of progress in synthetic carbohydrate chemistry

“…For the most part, medicinally important carbohydrates exist as complex oligomers or as conjugates with other biomolecules including natural products, lipids, peptides, proteins, etc. 2 The carbohydrate part itself exists in various sizes and shapes ranging from monomeric sugars and simple linear chains to highly branched glycoforms. Major obstacles in studying natural carbohydrates are the difficulties in isolating, characterizing, and synthesizing these molecules due to their low abundance and heterogeneity in nature.…”

Multi-strategy engineering unusual sugar TDP-l-mycarose biosynthesis to improve the production of 3-O-α-mycarosylerythronolide B in Escherichia coli

“…Glycosylated natural products have diverse bioactivity and improved properties, which are closely associated with the structure and attachment pattern of the sugar units [ 1 , 2 ]. It has been well explored that the sugar moiety of many therapeutic agents participates in the interaction between the drug and cellular target which enables effective drug targeting and improved pharmacological properties [ [3] , [4] , [5] , [6] , [7] ].…”

Synthesis, Characterization and Physicochemical Analysis of some Mannofuranoside Derivatives with Potent Antimicrobial Activity

“…19 furthermore, when biologically active molecule is connected to another nuclei may possess excellentbiological activity. 20 Several glycoconjugates such as glycolipids, glycoproteins or glycopeptides & glycosylated natural products are frequently being used as antimicrobial drugs and also emerging as anti-cancer drug candidates [21][22][23][24][25][26][27][28] . Encouraged by these results, we have synthesized some glycosides for antibacterial and antifungal evaluation.…”