ChemInform Abstract: Bu₄NI‐Catalyzed Construction of C—O Bonds by Oxidative Coupling of Alcohols with Ethers.

Abstract

WANG, Q.; FENG, J.; CHAI, W.; GENG, H.; XU, M.; WANG, K.; XU, C.; FU, R.; YUAN*, R.; Tetrahedron Lett. 55 (2014) 34, 4785-4789, http://dx.

An Efficient, Eco-friendly and Sustainable One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Directly from Alcohols Catalyzed by Heteropolyanion-Based Ionic Liquids

“…Based on our previous investigations into HPAILs catalyzed reactions [ 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 ], N -substituted imidazole, pyridine and triethylamine based HPAILs were chosen as potential catalysts for this tandem oxidative cyclocondensation ( Figure 1 ).…”

“…Recently, a large number of publications have clearly shown that the main benefit of microwave (MW) chemical processing is the significant rate enhancements, yield and selectivity improvements as well as less environmental pollution, matching with the goals of green chemistry [ 100 , 101 , 102 ]. Following our continued investigation into the development of useful and sustainable synthetic methodologies [ 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 ]—along with recent investigations involving oxidation of alcohols and the subsequent trapping of carbonyl intermediates with appropriate nucleophiles in a one-pot operation. [ 112 ]—herein, we report an efficient and environmentally benign TOPs for the Biginelli reaction, starting directly from alcohols, using HPAILs as catalysts and NaNO 3 as an oxidant under MW and solvent-free conditions ( Scheme 1 ).…”