Abstract:Benzolactam Growth Hormone Secretagogues: Replacement of the C-3 Amide Bond in L-692,429.-General benzolactams are created as potential new nonpeptidyl growth-hormone secretagogues on the basis of the known L-692429. It can be shown that the substitution of the C-3 amide bond by an urea moiety results in the formation of compounds like (IV), which have equal activity compared with the parent compound. -(OK, H. O.; SZUMILOSKI, J. L.; DOLDOURAS, G. A.; SCHOEN, W. R.; CHENG, K.; CHAN, W. W.-S.; BUTLER, B. S.; SMI… Show more
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