ChemInform Abstract: Aza‐Michael Access to Fluoroalkylidene Analogues of Biomolecules.

Abstract

Aza-Michael Access to Fluoroalkylidene Analogues of Biomolecules. -A direct access for the preparation of fluoroallylamines via aza-Michael reaction followed by a modified Julia reaction is presented. This method also allows the synthesis of fluorovinylic acyclic nucleoside (XIV), which exhibits anti-cancer properties, as well as the synthesis of the DPP-II inhibitor (XVIII). -(PRUNIER, A.; CALATA, C.; LEGROS, J.; MADDALUNO, J.; PFUND, E.; LEQUEUX*, T.; J. Org. Chem. 78 (2013) 16, 8083-8097, http://dx.