ChemInform Abstract: Asymmetric Syntheses of 3,4‐Disubstituted Tetrahydroquinoline Derivatives Using (+)‐Sparteine‐Mediated Electrophilic Substitution.

Abstract

A novel methodology for the asymmetric synthesis of trans‐3,4‐diaryl‐substituted tetrahydroquinolines via sparteine‐assisted stereoselective lithiation of o‐substituted N‐pivaloylanilines (I), kinetic resolution of epoxides in substitution and a stereospecific Mitsunobu cyclization is developed.